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Related Experiment Videos

[Rheologic studies in chronic agressive hepatitis].

H Leonhardt, H J Bungert

    Zeitschrift Fur Gastroenterologie
    |October 1, 1975
    PubMed
    Summary

    Fluocortolone monotherapy normalized lab markers in chronic aggressive hepatitis by reducing immunoglobulin G (IgG) levels. This improved blood viscosity and microcirculation, aiding inflammation regression.

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    Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

    Leukemia·2017

    Area of Science:

    • Hepatology
    • Immunology
    • Rheology

    Context:

    • Chronic aggressive hepatitis type IIb is characterized by elevated plasma and blood viscosity.
    • Inflammation severity correlates with increased viscosity, primarily due to pathological immunoglobulin fractions.
    • Current treatments lack focus on rheological improvements.

    Purpose:

    • To investigate the effect of fluocortolone monotherapy on viscosity and inflammatory markers in chronic aggressive hepatitis.
    • To correlate changes in blood viscosity with specific immunoglobulin levels and clinical parameters.
    • To assess the impact of improved blood flow on microcirculation and cellular nutrition.

    Summary:

    • Fluocortolone monotherapy led to the regression and normalization of laboratory parameters typical for aggressive hepatitis.
    • A significant decrease in blood and plasma viscosity was observed during treatment.
    • The reduction in viscosity was attributed to a decrease in the immunoglobulin G (IgG) fraction.

    Impact:

    • Improved blood flow properties due to decreased IgG fractions enhance microcirculation.
    • Better cellular nutrition and regression of inflammatory parameters are potential benefits.
    • Cortisone therapy may offer significant advantages in managing aggressive hepatitis by addressing rheological aspects.

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