IgG catabolism in anephric patients

The catabolism of purified human 125I labelled IgG has been studied in patients with chronic renal failure, both nephrectomised and non-nephrectomised, on intermittent haemodialysis. In all patients the T 1/2 of IgG was the same as in normal controls, and using chromatographic separation on Sephadex G200, there was no evidence of alteration of molecular size as a result of dialysis. The results do not support the notion that the kidney is an important site of IgG catabolism in humans.