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Related Experiment Videos

Dinitrochlorobenzene contact sensitization in pulmonary tuberculosis.

A N Malaviya, K L Sehgal, R Kumar

    Clinical and Experimental Immunology
    |December 1, 1975
    PubMed
    Summary

    Pulmonary tuberculosis patients show reduced skin sensitization to DNCB, indicating subtle immunodeficiency. This immune function improves with clinical recovery, suggesting a link between disease status and immune response.

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    Area of Science:

    • Immunology
    • Infectious Diseases
    • Pulmonary Medicine

    Background:

    • Pulmonary tuberculosis (TB) is a significant global health concern.
    • Cell-mediated immunity plays a crucial role in host defense against TB.
    • Assessing immune function in TB patients is vital for understanding disease pathogenesis and treatment response.

    Purpose of the Study:

    • To investigate the immune status of patients with pulmonary tuberculosis.
    • To evaluate skin sensitization responses in active, treated, and untreated TB patients compared to healthy controls.
    • To explore the correlation between clinical improvement and immune function in pulmonary TB.

    Main Methods:

    • Skin sensitization tests using 2,4-dinitrochlorobenzene (DNCB) were performed on 45 untreated, 106 on-treatment, and 15 fully treated TB patients, alongside 55 healthy controls.

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  • The Mantoux test with purified protein derivative (PPD) was administered concurrently.
  • DNCB sensitization levels were quantified and compared across groups.

    • Main Results:

    • Healthy controls demonstrated robust DNCB sensitization (majority 4+).
    • Untreated and active on-treatment TB patients exhibited significantly impaired DNCB sensitization compared to controls.
    • Fully treated patients showed partial recovery of DNCB sensitization, though still lower than controls.
    • All patient groups and controls showed high Mantoux positivity.

    Conclusions:

    • Pulmonary tuberculosis is associated with a degree of immunodeficiency, specifically affecting cell-mediated immunity.
    • Immune function, as indicated by DNCB sensitization, gradually improves with clinical recovery from pulmonary TB.
    • These findings highlight the impact of TB on the immune system and its potential for recovery.