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Thyrotropin-releasing hormone and amphetamine: a comparison of pharmacological profiles in animals
P J Manberg1, C B Nemeroff, A J Prange
1Department of Psychiatry and Pharmacology, University of North Carolina, School of Medicine, Chapel Hill.
Progress in Neuro-Psychopharmacology
|January 1, 1979
Abstract:
1. The pharmacological effects of TRH are compared to those produced by d-amphetamine in an attempt to elucidate the mechanisms underlying the activity of this endogenous peptide. 2. Although numerous amphetamine-like actions have been attributed to TRH, several differences have been noted between these compounds and are discussed. 3. At present, it is impossible to propose a single mechanism of action to explain the behavioral effects of TRH.