Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lichen sclerosus et atrophicus: an electron microscopic study.

A Kint, M L Geerts

    Journal of Cutaneous Pathology
    |January 1, 1975
    PubMed
    Summary

    Ultrastructural analysis revealed significant changes in lichen sclerosus et atrophicus (LSA). Key findings include altered basal cells, basement membrane irregularities, and disturbed dermo-epidermal interactions in LSA.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Primary cutaneous marginal zone B-cell lymphoma: clinical and therapeutic features in 50 cases.

    Archives of dermatology·2005
    Same author

    CD-34 and Ki-67 staining patterns of basaloid follicular hamartoma are different from those in fibroepithelioma of Pinkus and other variants of basal cell carcinoma.

    Journal of cutaneous pathology·2001
    Same author

    Guess what! Angiosarcoma of the face and scalp.

    European journal of dermatology : EJD·2000
    Same author

    Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment.

    Blood·2000
    Same author

    Pyoderma gangrenosum as an early revelator of acute leukemia.

    Dermatology (Basel, Switzerland)·2000
    Same author

    Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients.

    Archives of dermatology·2000

    Area of Science:

    • Dermatopathology
    • Electron Microscopy
    • Connective Tissue Biology

    Background:

    • Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory skin condition.
    • Its precise ultrastructural pathology remains incompletely understood.
    • Understanding LSA's ultrastructure is crucial for diagnosis and management.

    Purpose of the Study:

    • To describe the detailed ultrastructural alterations in seven cases of lichen sclerosus et atrophicus.
    • To elucidate the changes occurring at the dermo-epidermal junction and within the dermis.
    • To identify key ultrastructural markers associated with LSA.

    Main Methods:

    • Transmission electron microscopy was employed to examine tissue samples.
    • Seven biopsy specimens from patients diagnosed with lichen sclerosus et atrophicus were analyzed.
    • Detailed ultrastructural examination focused on epidermal, basement membrane, and dermal components.

    Main Results:

    • Epidermal alterations included collagen fibrils in intercellular spaces and altered basal cell tonofibrils.
    • The basement membrane showed non-uniformity and multilayering, with numerous anchoring fibrils.
    • The dermis contained a mix of fine filaments, immature collagen, and normal collagen bundles.
    • A disturbed dermo-epidermal interrelationship was a consistent finding.

    Conclusions:

    • Lichen sclerosus et atrophicus exhibits distinct and complex ultrastructural changes.
    • These changes involve epidermal cells, the basement membrane complex, and dermal extracellular matrix.
    • The findings highlight a significant disruption of the dermo-epidermal interface in LSA.

    Related Experiment Videos