[Protective effect of beta-adrenergic substances on the allergic rhinitis (author's transl)]

The protective and curative effect of Th 1165a (Fenoterol) and Salbutamol on the allergic rhinitis is reported. 70 patients with positive nasal provocation tests (speezing, rhinitis and eosinophilia of the secretions) were tested some days later with the same allergen after application of 100 mug TH 1165a. Protective effect could be shown in 64 patients who did not react with clinical symptoms. Another 85 patients were treated in the same way after a positive nasal provocation test and the clinical symptoms disappered within 5 minutes. In 10 patients nasal resistance was measured objectively by bodyplethysmography. Salbutamol showed the same protective and curative effect in 30 patients proved in the same way as described before. Application of the substances in the contralateral nostril had no systemic effect.