[Influence of epiphysectomy on the metabolism of electrolytes]

On the 5th day after epiphysectomy rats displayed a reduction of the kidney excretion of Ca and Mg with a simultaneous increase of these elements in the tissues. By the 10th day after the operation the mentioned indices were restored to the preoperative level, but there occurred an increase in the urinary excretion of Na and a reduction of its tissue content. DOCA administration to the epiphysectomized rats eliminated the changes in the Mg and Ca excretion, but failed to influence the Na excretion. Apparently, the hormones of the epiphysis are necessary for the manifestation of the Na-retention action of the mineralocorticoids.