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Miconazole in coccidioidomycosis.
1University of California, Oakland.
Proceedings of the Royal Society of Medicine
|January 1, 1977
Summary
Miconazole demonstrated significant efficacy against Coccidioides immitis infections in mice and showed promising results in human patients, including those critically ill, who had not responded to other treatments.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Pharmacology
Background:
- Coccidioides immitis causes significant morbidity and mortality, with varying ethnic susceptibilities.
- Existing therapies for coccidioidomycosis have limitations, particularly in severe or refractory cases.
Purpose of the Study:
- To evaluate the efficacy of miconazole against Coccidioides immitis.
- To assess the therapeutic potential of miconazole in a murine model and in human patients with coccidioidomycosis.
Main Methods:
- Murine model of Coccidioides immitis infection treated with miconazole.
- In vitro sensitivity testing of miconazole against different forms of Coccidioides immitis.
- Clinical data analysis of 14 human patients with coccidioidomycosis treated with miconazole.
Main Results:
- Miconazole achieved 100% survival in infected mice under lethal conditions.
- Miconazole was more effective against the endospore form of the fungus than the mycelial form.
- Eight of 14 human patients showed objective improvement, with a majority experiencing subjective benefit.
Conclusions:
- Miconazole exhibits potent antifungal activity against Coccidioides immitis, particularly the endospore form.
- Miconazole represents a potential therapeutic option for coccidioidomycosis, including severe and treatment-refractory cases.