Inhibited adenine nucleotide translocation in mitochondria isolated from ishcemic myocardium

Experiments conducted in healthy mongrel dogs indicate that acyl-CoA levels are raised and adenine nucleotide translocase is inhibited during ischemia. The biochemical findings are accompanied by ultrastructural evidence of myocardial cell damage. These results raise the possibility that the inhibition of adenine nucleotide translocase may be a key disturbance in cellular metabolism.