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Subdermal levonorgestrel implants and pituitary function.

M I Abdalla, M A Shafeek, M M Fayad

    Contraceptive Delivery Systems
    |September 1, 1983
    PubMed
    Summary
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    Subdermal levonorgestrel implants did not significantly alter circulating follicle-stimulating hormone (FSH), luteinizing hormone (LH), or prolactin levels in women over six months. Hormone levels remained stable in both regularly menstruating and amenorrheic users.

    Area of Science:

    • Reproductive Endocrinology
    • Pharmacology

    Background:

    • Subdermal levonorgestrel implants are a widely used reversible contraceptive method.
    • Understanding the hormonal impact of these implants is crucial for assessing their safety and efficacy.
    • Follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin are key reproductive hormones that may be affected by hormonal contraceptives.

    Purpose of the Study:

    • To investigate the changes in circulating levels of FSH, LH, and prolactin in women using subdermal levonorgestrel implants.
    • To compare hormonal profiles between regularly menstruating and amenorrheic women using these implants.

    Main Methods:

    • A cohort of 21 women using subdermal levonorgestrel implants was studied.
    • Blood samples were collected at baseline (pre-implantation), 1 month, and 6 months post-implantation.
    Keywords:
    Age FactorsAmenorrheaBiologyContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptive Agents, ProgestinContraceptive ImplantsContraceptive MethodsDiseasesEndocrine SystemFamily PlanningFollicle Stimulating Hormone--analysisGonadotropinsGonadotropins, PituitaryHormonesLevonorgestrelLuteinizing Hormone--analysisMenstruationMenstruation DisordersParityPhysiologyPituitary GlandPituitary HormonesProlactin--analysisReproductionReproductive Control Agents

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  • Hormone levels (FSH, LH, prolactin) were measured during the early follicular phase in menstruating women and randomly in amenorrheic women.

    • Main Results:

    • No statistically significant differences were observed in mean FSH, LH, or prolactin levels at the three time points (baseline, 1 month, 6 months).
    • These findings were consistent in both the regularly menstruating (n=12) and amenorrheic (n=9) subgroups.
    • The subdermal levonorgestrel implants did not appear to disrupt the measured circulating hormone levels within the study period.

    Conclusions:

    • Subdermal levonorgestrel implants do not significantly alter circulating FSH, LH, and prolactin levels in women users.
    • The hormonal contraceptive appears to maintain stable levels of these key reproductive hormones.
    • This suggests a lack of significant endocrine disruption related to these specific hormones during the use of levonorgestrel implants.