[131-I-hippuran clearance and isotopic nephrography in patients with endemic nephropath]

The authors carried out investigations on renal function with isotope nephrogram and 131J-hippuran clearance in 30 patients with endemic nephropathy - three with and 27 without nitrogen retention. In all patients, especially in advanced stages, a considerable decrease of the effective renal plasma flow was established. The radioisotope nephropathy also provides evidence for diffuse bilateral and symetric alterations in the complete renal function. The statement was confirmed that in the course of endemic nephropathy, all renal structures are gradually involved, but the functions of tubules and interstitial tissues are especially severly disturbed.