[Proteinuria selectivity in patients with glomerular nephropathy determined by a biochemical route]

The authors applied a new method for biochemical determination of proteinuria selectivity by means of ceruloplasmin clearance, used as a protein with high molecular weight as well as those of haptoglobulin and albumin -used as proteins with low molecular weight. The investigation was carried out among 94 patiens with different glomerulopathies. The equivalence of both the biochemical methods was confirmed statistically. In 58 of the examined patients, proteinuria selectivity is determined simultaneously and by the JgG clearance and trasferrin-accoringing to the method of Cameron et al. (with immunodiffused plaques) and immunoelectrophoresis and by the clearance of alpha2-macroglobulin and transferrin. Nd. statistically significant and authenical differences were established between the proteinuria selectivity determined by the relationship between the clearances of ceruloplasmin and albumin, of ceruloplasmin and haptoglobulin (biochemically determined) and of Jg G and transferrin (determined with the aid of immunodiffused plaques and immunoelectropphoresis). All that gives ground the authors to consider the results from the biochemical and immunochemical methods rather similar. That fact, the low prime cost and the possibility the biochemical methods to be put into practice in well equipped clinical laboratories emphasize their importance for the everyday nephrologist practice as well.