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Effects of locally injected interferon-beta on palatal mucoperiosteal wound healing
A M H Cornelissen1, J W Von den Hoff, J C Maltha
1Department of Orthodontics and Oral Biology, University Medical Centre Nijmegen, University of Nijmegen, the Netherlands.
Background:
Wound contraction and scar formation in the palatal mucoperiosteum after cleft palate surgery impair maxillary growth. The aim of this study was to determine the effects of IFN-beta on palatal mucoperiosteal wound healing in growing rats.
Methods:
Standardized wounds were made in the palatal mucoperiosteum of young rats. Either IFN-beta or vehicle were injected at the wound site between 4 and 29 days after wounding. The results were compared with control wounds. Tissue samples were collected at 8, 15, 30, and 60 days PW for biochemical and microscopic analysis.
Results:
IFN-beta stimulated re-epithelialization but did not reduce the number of myofibroblasts or scar tissue formation. Surprisingly, the injection of vehicle alone delayed the healing process.
Conclusion:
IFN-beta might be suitable to stimulate re-epithelialization but it does not reduce scar tissue formation in rat palatal wound healing. The injection of agents into palatal wounds might severely impair the healing process.