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Neuroprotection against ischemic brain injury conferred by a novel nitrate ester
James N Reynolds1, Brian M Bennett, Roland J Boegman
1Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, Canada.
Bioorganic & Medicinal Chemistry Letters
|September 25, 2002
Abstract:
Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.