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Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant
Stephen Hanessian1, Eric Therrien, Kenneth Granberg
1Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-ville, Montréal, QC, Canada. stephen.hanessian@umontreal.ca
Bioorganic & Medicinal Chemistry Letters
|September 25, 2002
Abstract:
Guided by molecular modeling, docking experiments, and available X-ray crystal structure data on the serine protease Factor VIIa and thrombin, a series of indolizidinone derivatives was designed and synthesized having diverse functionality at the P1, P2, and P3 sites.