Related Experiment Videos
Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC)
Michael L Curtin1, Robert B Garland, H Robin Heyman
1Cancer Research Area, Abbott Laboratories, Dept. 47J, Bldg. AP10, 100 Abbott Park Road, Abbott Park, IL 60064, USA. mike.curtin@abbott.com
Bioorganic & Medicinal Chemistry Letters
|September 25, 2002
Abstract:
A series of succinimide hydroxamic acids was prepared and evaluated in vitro for HDAC inhibition and tumor cell antiproliferation. While the original macrocyclic analogue 6 was quite potent in both assays, several appropriately substituted non-macrocyclic succinimides, such as 23, were equipotent.