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Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization
Steven D Linton1, Donald S Karanewsky, Robert J Ternansky
1Idun Pharmaceuticals, Inc., 9380 Judicial Drive, San Diego, CA 92121, USA. slinton@idun.com
Bioorganic & Medicinal Chemistry Letters
|September 25, 2002
Abstract:
A new structural class of broad spectrum caspase inhibitors was optimized for its activity against caspases 1, 3, 6, 7, and 8. The most potent compound had low nanomolar broad spectrum activity, in particular, single digit nanomolar inhibitory activity against caspase 8.