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Tumor necrosis factor-alpha inhibits physiologically identified dorsal motor nucleus neurons in vivo

Gregory S Emch1, Gerlinda E Hermann, Richard C Rogers

  • 1Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
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