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c-erbB2 over-expression in endometrial hyperplasia induced by estrogens
Hugo Maia1, Amélia Maltez, Célia Athayde
1CEPARH, Rua Caetano Moura, 35 Salvador, 40210-341, Bahia, Brazil. ceparh@uol.com.br
Objective:
To determine whether the presence of c-erbB2 expression in both spontaneous and estrogen-induced hyperplasia can affect the number of Ki-67-positive cells.
Patients And Methods:
Thirty-two postmenopausal women with endometrial hyperplasia occurring spontaneously or after using unopposed estrogens were studied. The number of cells undergoing mitosis was estimated by immunohistochemical detection of the Ki-67 antigen and compared with the presence or absence of c-erbB2 over-expression.
Results:
The percentage of cell nuclei showing positivity for Ki-67 was significantly higher in cases of endometrial hyperplasia that displayed c-erbB2 over-expression when compared to negative cases.
Conclusion:
The presence of c-erbB2 over-expression in endometrial hyperplasia is associated with a higher number of cells being positive for the Ki-67 proliferation marker.