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Diurnal variations in coagulation and fibrinolysis in vital exhaustion

Rob van Diest1, Karly Hamulyák, Willem J Kop

  • 1Department of Psychiatry, Maastricht University, Maastricht, The Netherlands. rob.vandiest@pn.unimaas.nl

Psychosomatic Medicine
|September 25, 2002
PubMed

Insights

Vital exhaustion (VE) is linked to reduced early morning fibrinolysis and higher fibrinogen levels. These hemostatic changes may increase the risk of myocardial infarction (MI) and related cardiac events.

Area of Science:

  • Cardiology
  • Hematology
  • Psychosomatic Medicine

Background:

  • Vital exhaustion (VE) is a known predictor of myocardial infarction (MI) and adverse cardiac events post-angioplasty.
  • The pathophysiological mechanisms linking VE to cardiac events require further elucidation.

Purpose of the Study:

  • To investigate the association between vital exhaustion (VE) and diurnal variations in hemostasis.
  • To explore potential underlying mechanisms linking VE to increased cardiovascular risk.

Main Methods:

  • Blood samples were collected from 29 VE and 30 control males at 7:00 AM and 6:00 PM.
  • Hemostatic measures, including fibrinolysis and coagulation markers, were assessed.

Main Results:

  • Fibrinolytic measures showed more pronounced diurnal variations in VE individuals, with decreased early morning fibrinolytic capacity.
  • Coagulation measures (F1+2, thrombin-antithrombin complexes, activated factor VII) exhibited similar diurnal variations in both VE and control groups.
  • Prothrombin fragment 1+2 (F1+2) and fibrinogen levels were significantly higher throughout the day in individuals with VE.

Conclusions:

  • Vital exhaustion (VE) is associated with diminished early morning fibrinolysis and elevated daily fibrinogen levels.
  • These hemostatic alterations may contribute to thrombus formation, offering a potential mechanism linking VE to MI and its circadian patterns.
Abstract

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