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Assembly of polyamines via amino acids from three components using cobalt(III) template methodology
Gilles Laval1, William Clegg, Christopher G Crane
1Department of Chemistry, Bedson Building, University of Newcastle upon Tyne, Newcastle upon Tyne, UK NE1 7RU.
Chemical Communications (Cambridge, England)
|September 26, 2002
Abstract:
A versatile and efficient template synthesis has been developed to synthesise novel polyamines [e.g. rac-N3-(3-aminopropyl)butane-1,3-diamine, isospermidine 1] via amino acids [e.g. (2R,4S/2S,4R)-N4-(3-aminopropyl)-2,4-diaminopentanoic acid] using cobalt(III) to assemble the three precursor components in a biomimetic manner.