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Is the pill getting safer?

    IPPF Medical Bulletin
    |June 1, 1972
    PubMed
    Summary

    Mortality linked to oral contraceptives in England significantly decreased by 1970, suggesting a parallel reduction in related health issues. This trend emerged as the number of oral contraceptive users returned to pre-publicity levels.

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    Area of Science:

    • Public Health
    • Pharmacovigilance
    • Epidemiology

    Background:

    • The Office of Population Census and Surveys monitors drug-related mortality in the UK.
    • Oral contraceptives (OCs) have been scrutinized for potential adverse effects.
    • Previous adverse publicity in 1969 may have influenced reporting and usage.

    Purpose of the Study:

    • To analyze trends in drug-related mortality, with a focus on oral contraceptives.
    • To assess the relationship between OC usage, adverse publicity, and mortality rates.
    • To evaluate the accuracy and completeness of death certification regarding OCs.

    Main Methods:

    • Analysis of death registration data from 1967-1970 in England.
    • Categorization of deaths by implicated therapeutic drug class.
    • Examination of specific causes of death attributed to oral contraceptives (e.g., venous thrombosis, coronary thrombosis).

    Main Results:

    • Deaths implicating oral contraceptives decreased from 28 in 1969 to 13 in 1970.
    • Major causes of OC-related deaths included venous thrombosis and embolism, and coronary thrombosis.
    • Data suggest a material decrease in OC-related mortality, potentially paralleled by reduced morbidity.

    Conclusions:

    • Mortality associated with oral contraceptives appears to have significantly declined.
    • The decline may be linked to reduced usage or other factors following adverse publicity.
    • Challenges in death certification accuracy necessitate cautious interpretation of causality.
    Keywords:
    ContraceptionContraceptive AgentsContraceptive Agents, EstrogenContraceptive Agents, FemaleContraceptive MethodsDeveloped CountriesEuropeFamily PlanningMortalityNorthern EuropeOral ContraceptivesUnited KingdomWestern Europe

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