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Related Experiment Videos

[Thyroid gland function in heatstroke].

O V Molotkov, N B Kozlov

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |July 1, 1975
    PubMed
    Summary

    High external temperatures induce thermal stroke in rats, significantly reducing thyroid iodine uptake and thyroxine levels in blood plasma. This indicates a disruption in thyroid hormone regulation during heat stress.

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    Area of Science:

    • Endocrinology
    • Environmental Physiology
    • Biochemistry

    Context:

    • Exposure to extreme heat (45°C) can induce thermal stroke.
    • Thyroid gland function is crucial for regulating metabolic processes.
    • Iodine metabolism is central to thyroid hormone synthesis.

    Purpose:

    • To investigate the impact of acute heat stress on thyroid gland function and iodine metabolism in rats.
    • To analyze changes in thyroid hormone precursors and circulating thyroid hormones during thermal stroke.

    Summary:

    • Thermal stroke in rats exposed to 45°C led to decreased radioiodine (I131) accumulation in the thyroid gland.
    • A reduction in protein-bound iodine-131 and thyroxine levels was observed in peripheral blood plasma.
    • Analysis of thyroid gland hydrolysates revealed decreased levels of iodinated tyrosine derivatives (mono- and diiodothyrosines) and iodothyronines.

    Impact:

    • This study highlights the detrimental effects of acute heat stress on thyroid function.
    • Findings suggest impaired thyroid hormone synthesis and release under severe thermal conditions.
    • Provides insights into the physiological mechanisms underlying heat-induced endocrine disruption.

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