[Effect of chloridine on some biochemical indices in pregnant rats]

Experiments conducted on rats demonstrated that introduction of chloridine (35 mg/kg) on the 13th day of gestation causes maldevelopment of the fetuses in 81.5 per cent of the cases. The blood serum of female-rats receiving the teratogenic compound showed a change in the content of the pre-albuminic and albuminic fractions, the appearance of an unusual proteinic band in the beta-globulins zone and also perversion of the isoenzymatic spectrum of the serumal lactate-dehydrogenase, as well as a 2.9-fold increase of its specific activity.