Ultrastructural and histochemical study of the adrenal medulla in normal and cold-stressed Syrian hamsters

The effect of 24 and 48 hours' cold stress on the hamsters' adrenomedullary follicles and on the medullary ATPase activity was studied by light and electron microscopy. Only norepinephrine cells were depleted after this stress, and exocytosis seemed to be the mechanism involved in the release of catecholamine. Follicles containing these cells expanded and their lumina became narrow. A few other cellular and follicular changes also occurred and are described. ATPase activity was apparent in control organs along the endothelial linings, in neural elements and macrophages, and in approximately 40% of the linings of follicular lumina. Cold stress did not alter this pattern. These results have been compared with previous findings and the possible functions of the follicular lumina are discussed. It is concluded that they are unlikely sites for catecholamine storage or release.