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Provocation tests with antiphlogistica and food additives in recurrent urticaria
Dermatologica
|January 1, 1975
Summary
Recurrent urticaria in 100 patients was linked to food additives. Many experienced reactions to common substances like aspirin and azo dyes, with some showing multiple sensitivities.
Area of Science:
- Allergy and Immunology
- Dermatology
- Clinical Pharmacology
Background:
- Recurrent urticaria is a common condition often triggered by external factors.
- Identifying specific triggers is crucial for effective patient management.
Purpose of the Study:
- To investigate the role of various food additives in triggering recurrent urticaria.
- To identify the most frequent causative agents among dye additives, preservatives, and antiphlogistics.
Main Methods:
- A cohort of 100 patients with recurrent urticaria underwent testing for reactions to 8 dye additives, 7 preservatives, and 7 antiphlogistics.
- Patient reactions, including urticaria and angio-oedema, were meticulously recorded.
- Frequency of reactions to individual substances and combinations was analyzed.
Main Results:
- 62 out of 100 patients exhibited reactions to tested food additives.
- Aspirin (33.75%), azo dyes tartrazine (20.83%) and sunset yellow (15.12%), and dextropropoxyphene (24.44%) were the most frequent triggers.
- 39 patients reacted to multiple substances, while 23 reacted to a single substance.
Conclusions:
- Food additives, particularly certain dyes and antiphlogistics, are significant triggers for recurrent urticaria.
- A substantial proportion of patients exhibit polysensitization to multiple food additives.
- Further research into additive-induced urticaria is warranted for improved diagnostic and therapeutic strategies.