Effect of vitamin A on 2,2-bis-(p-chlorophenyl), 1,1-dichloroethylene concentration in rat liver

Residual amounts of 2, 2-bis-(p-chlorophyenyl), 1, 1-dicholroethylene (p,p' DDE) and the concentrations of total lipids and triglyceride were studied with respect to the internal organs of rats which had been dosed with p,p' DDE and fed on the diet free from vitamin A or containing excess of vitamin A. Either the absence or excess of vitamin A was found to increase triglyceride content and p,p' DDE storage level in the liver. However, the ratio of p,p' DDE stroage level in the liver to content of liver triglyceride was almost constant independently of the vitamin A treatment. It is suggested that the dose of vitamin A has some influences upon the metabolic processes of liver triglyceride in rats and changes the storage level of P,P'DDE in the organ.