[Histamine content in the tissue of lower limbs in varicose veins]

The histamine level was studied in the skin, subcutaneous cellular tissue, and in the vein of the upper third of the femur and lower third of the medial crural surface in 24 patients with venous varicosity of the lower extremities. The histamine concentration in the femoral skin was found to be within normal physiological limits. The histamine content in crural tissue was dependent on the presence of trophic changes in the skin, and it was the higher the more grave were these changes. As a result, the authors make a conclusion that histamine plays some role in formation of general microcirculatory shifts characteristic of development of trophic disorders in the skin in case of the disease concerned.