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Updated: Aug 12, 2026

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Published on: February 26, 2019
[Extraction and characterization of a gastrosecretagogue peptide from the pancreas (author's transl)]
Abstract:
A peptide which stimulates gastric acid secretion in the rat has been isolated from the normal porcine pancreas. It consists of 13 amino acids and has a molecular weight of 1286. It has been named GSP (gastrosecretagogue pancreatic peptide) on account of its main biological activity. Although its influence on gastric acid secretion is gastrin-like, there are marked biochemical and immunological differences between gastrin and GSP. The two substances are separable from each other by Sephadex gel filtration, by ion-exchange chromatography, and by disc electrophoresis. Furthermore, there are differences in the UV-absorption spectrum and in the amino acid composition. GSP does not react with gastrin antibodies in a radioimmunological system. GSP is considered to be a new polypeptide hormone by means of which the pancreas plays a role in the regulation of gastric acid secretion.
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