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Related Experiment Video

Updated: Jul 13, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Transplanted neuronal precursors migrate and differentiate in the developing mouse brain.

Wei Min Peng1, Li Li Yu, Chun Ying Bao

  • 1Biomedical Research Institute, Beijing Normal University, China.

Cell Research
|September 26, 2002
PubMed
Summary

Adult mouse subventricular zone (SVZ) neuronal precursors can survive and migrate within the brain after transplantation. These cells retain their ability to proliferate and differentiate, suggesting potential for neural repair.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The subventricular zone (SVZ) in adult mammals contains neuronal precursors capable of proliferation.
  • Understanding the potential of these adult SVZ cells is crucial for regenerative medicine.

Purpose of the Study:

  • To investigate the survival, migration, and differentiation potential of adult SVZ neuronal precursors after transplantation into the mouse brain.
  • To determine if the developmental stage of the recipient brain influences the fate of transplanted SVZ cells.

Main Methods:

  • Adult mouse SVZ cells were labeled with PKH26 fluorescent dye.
  • Cells were transplanted into the lateral ventricle of recipient mice at various developmental stages.
  • Grafted cell survival, migration, and differentiation were assessed using immunohistochemistry.

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Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains
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Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices
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Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

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Last Updated: Jul 13, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains
06:09

Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains

Published on: August 26, 2019

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices
04:17

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

Main Results:

  • Transplanted SVZ cells survived and migrated to multiple brain regions, including the SVZ, thalamus, cerebellum, and olfactory bulb.
  • Cell survival and migration patterns were correlated with the recipient brain's developmental stage.
  • Migrated cells expressed neuronal and astrocytic markers, indicating differentiation potential.

Conclusions:

  • Adult SVZ neuronal precursors retain self-renewal and multipotency.
  • The adult brain environment influences the behavior of transplanted SVZ cells.
  • These findings highlight the potential of adult SVZ cells for neural regeneration.