Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subthalamotomy for advanced Parkinson disease.

Philip C Su1, Ham-Min Tseng, Hon-Man Liu

  • 1Department of Neurology, National Taiwan University Hospital, Taipei, ROC. philipsu@ha.mc.ntu.edu.tw

Journal of Neurosurgery
|September 26, 2002
PubMed
Summary

Subthalamotomy effectively treats advanced Parkinson disease (PD) by improving motor symptoms and reducing medication needs. Bilateral procedures showed greater benefits, though some side effects like hemiballismus occurred.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic value of immediate and short-term postoperative biochemical markers for long-term remission in acromegaly: A single-center study.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2026
Same author

Early alcohol initiation is associated with higher lifetime Parkinson's disease risk after accounting for exposure latency.

Journal of Parkinson's disease·2026
Same author

Acute Ischemic Stroke Lesion Characterization: Comparative Analysis of Cortical and Basal Ganglia Lesions Using Time-Histogram Metrics.

Diagnostics (Basel, Switzerland)·2026
Same author

Detecting Basilar Artery Wall Pathology in Isolated Pontine Infarction With Short-TE SWI Magnitude Images.

Stroke (Hoboken, N.J.)·2026
Same author

Influence of interhospital transfer on endovascular thrombectomy outcome in acute ischemic stroke patients: an analysis of the TREAT-AIS registry.

Frontiers in neurology·2026
Same author

Deep learning-based basilar artery wall and lumen segmentation from 1-mm MR vessel wall imaging.

Scientific reports·2026

Area of Science:

  • Neurosurgery
  • Neurology
  • Movement Disorders

Background:

  • Advanced Parkinson disease (PD) presents significant motor and non-motor challenges.
  • Current treatments, including dopaminergic therapy, have limitations and complications.

Purpose of the Study:

  • To evaluate the efficacy of subthalamotomy in managing advanced Parkinson disease.
  • To assess the impact of subthalamotomy on motor symptoms and medication requirements.

Main Methods:

  • Stereotactic radiofrequency subthalamotomy guided by microelectrode mapping in eight PD patients.
  • Postoperative evaluation using the Unified PD Rating Scale (UPDRS) for up to 18 months.
  • Comparison of unilateral versus bilateral subthalamotomy outcomes.

Related Experiment Videos

Main Results:

  • Significant improvements in bradykinesia, rigidity, axial motor features, gait, and postural stability observed.
  • Sustained motor benefits up to 18 months, with some tremor improvement lost.
  • Reduced levodopa requirement by 66% (unilateral) and 38% (bilateral).
  • Bilateral subthalamotomy demonstrated superior efficacy compared to unilateral surgery.

Conclusions:

  • Subthalamotomy effectively ameliorates cardinal symptoms of Parkinson disease.
  • The procedure reduces levodopa dosage and associated drug complications.
  • Subthalamotomy improves the overall quality of life for advanced PD patients.