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A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

Ho-Sang Moon1, Eric M Jacobson, Sonya M Khersonsky

  • 1Department of Chemistry, New York University, New York, NY 10003, USA.

Journal of the American Chemical Society
|September 26, 2002
PubMed

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Destabilization of Microtubules01:45

Destabilization of Microtubules

The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...