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Mitotically active juvenile xanthogranuloma.

Ana Miguélez1, Jose Luis Rodríguez-Peralto, Angel Santos-Briz

  • 1Department of Dermatology, 12 de Octubre University Hospital, Madrid, Spain.

Archives of Pathology & Laboratory Medicine
|September 26, 2002
PubMed
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Classic juvenile xanthogranuloma, a rare histiocytic disorder, can exhibit features of the nonlipidized variant. This unusual case highlights a high mitotic index in a classic presentation.

Area of Science:

  • Dermatopathology
  • Histiocytic Disorders

Background:

  • Juvenile xanthogranuloma (JXG) is a benign histiocytic inflammatory condition.
  • JXG typically presents with distinct histologic patterns: classic and nonlipidized.

Observation:

  • A case of JXG in a 2-year-old girl presented as a pink ulcerated nodule.
  • Histopathologic examination revealed a cellular proliferation in the dermis and subcutaneous tissue.

Findings:

  • The JXG showed features of the classic type, including foamy histiocytes and Touton giant cells.
  • Unusually, the lesion also displayed areas resembling nonlipidized JXG and a high mitotic index (23 per 10 high-power fields).

Implications:

  • This case expands the understanding of JXG's histologic variability.

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  • It underscores the importance of considering mitotic activity in the differential diagnosis of JXG subtypes.