Related Experiment Video
Updated: Aug 4, 2026
10:42
Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
A method to compare four mouthrinses: time to gingivitis level as the primary outcome variable
R Yates1, B H Shearer, E Huntington
1Division of Restorative Dentistry, Dental School, Bristol, UK.
Journal of Clinical Periodontology
|September 26, 2002
Summary
This study found chlorhexidine highly effective in reducing gingivitis compared to other mouth rinses. Cetylpyridinium chloride and triclosan showed some benefits but were less effective than chlorhexidine for plaque and bleeding on probing.
Area of Science:
- Oral health research
- Pharmacology of oral hygiene agents
Background:
- The experimental gingivitis model is utilized for assessing antiplaque agents.
- Bleeding on probing (BOP) was used as the primary outcome measure.
Purpose of the Study:
- To evaluate the antiplaque and antigingivitis efficacy of different mouth rinses.
- To utilize time-dependent BOP as a primary endpoint.
Main Methods:
- A single-blind, randomized four-arm parallel group study with 76 healthy volunteers.
- Subjects achieved
- Rinses tested: 0.05% cetylpyridinium chloride (CPC), control fluoride, 0.2% chlorhexidine, and 0.3% triclosan. BOP, modified gingival index (MGI), and plaque index were recorded.
Main Results:
- Chlorhexidine demonstrated significantly higher efficacy across all measured parameters (BOP, MGI, plaque).
- CPC and triclosan showed no significant difference from the control for BOP.
- CPC and triclosan were significantly better than control for MGI and plaque, respectively, but not different from each other.
Conclusions:
- The experimental gingivitis model effectively differentiated the efficacy of chlorhexidine from other tested rinses.
- Modifications, such as adjusting group sizes, could enhance the method's specificity.
- The study design offers volunteer appeal through early exit criteria for high BOP levels.
