Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional analysis of the tissue-engineered stomach wall.

Yoshio Hori1, Tatsuo Nakamura, Dai Kimura

  • 1Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, Japan. hori@frontier.kyoto-u.ac.jp

Artificial Organs
|September 26, 2002
PubMed
Summary

Tissue engineering successfully regenerated stomach tissue in dogs using a collagen scaffold. The engineered tissue showed structural organization and key digestive components, offering potential for stomach reconstruction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severe autoimmune diffuse alveolar hemorrhage in children; early diagnosis and initiation of therapeutic plasma exchange may improve clinical outcomes.

Frontiers in pediatrics·2026
Same author

Pediatric Critical Hematology Oncology Referral Pathway for Extracorporeal Life Support: Standardized Evaluation and Transfer Can Improve Survival.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2025
Same author

30 second screening test and education reduce chronic pain incidence after blood donation: Large prospective observational study from Japan.

Medicine·2025
Same author

An adult right inguinal hernia and cryptorchidism treated simultaneously with laparoscopic transabdominal preperitoneal repair and laparoscopic orchiectomy: a case report.

Journal of surgical case reports·2024
Same author

Effect of Preoperative Oral Antibiotics and Mechanical Bowel Preparations on the Intestinal Flora of Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Single-Center Prospective Pilot Study.

Cureus·2024
Same author

Evaluating Airway Management in Patients With Trisomy 21 in the PICU and Cardiac ICU: A Retrospective Cohort Study.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2023

Area of Science:

  • Regenerative Medicine
  • Gastroenterology
  • Biomaterials Science

Background:

  • Gastric reconstruction after gastrectomy presents challenges.
  • Tissue engineering offers a promising alternative for organ repair and regeneration.
  • Acellular collagen scaffolds are biocompatible materials for tissue regeneration.

Purpose of the Study:

  • To evaluate the functional aspects of in situ tissue-engineered stomach wall.
  • To assess the structural and physiological integration of a collagen scaffold in a canine stomach model.
  • To determine the potential of this approach for stomach reconstruction.

Main Methods:

  • An acellular collagen sponge scaffold (4x4 cm) was implanted to replace the anterior stomach wall in beagle dogs.
  • After 16 weeks, explanted stomach specimens were analyzed using immunohistochemistry and physiological testing.

Related Experiment Videos

  • Evaluation focused on the regeneration of essential gastric structures and functional responses.

    • Main Results:

    • Regeneration of the proton pump and a thin muscle layer was observed in the tissue-engineered gastric tissue.
    • The engineered stomach wall exhibited a highly organized structure.
    • Acetylcholine-induced contraction, a key physiological function, was not observed in the regenerated tissue.

    Conclusions:

    • In situ tissue engineering with acellular collagen scaffolds can regenerate organized stomach tissue with essential components.
    • While functional deficits (e.g., muscle contraction) remain, the structural regeneration is promising.
    • This approach holds potential as an alternative for stomach reconstruction following gastrectomy.