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Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid

Undurti N Das1

  • 1EFA Sciences LLC, Norwood, Massachusetts, USA. undurti@hotmail.com

Nutrition (Burbank, Los Angeles County, Calif.)
|September 26, 2002
PubMed

Abstract:

For legal reasons this article has been removed by the publisher

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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