Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement: more than a 'guard' against invading pathogens?

Dimitrios Mastellos1, John D Lambris

  • 1The Protein Chemistry Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 401 Stellar-Chance Laboratories, Philadelphia, PA 19104, USA.

Trends in Immunology
|September 26, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New Analogs of the Compstatin Family of Clinical Complement Inhibitors with Low Picomolar Target Affinity.

Journal of medicinal chemistry·2026
Same author

Clinical C3 Inhibition With AMY-101 Reveals Novel Insights Into IL-8-Driven Inflammation in COVID-19.

Immunology·2025
Same author

'Complement-ing' tissue inflammation via granzyme K?

Nature immunology·2025
Same author

Cp40-mediated complement C3 inhibition dampens inflammasome activation and inflammatory mediators storm induced by Bitis arietans venom.

International immunopharmacology·2025
Same author

The C5a/C5aR1 Axis Promotes Migration of Tolerogenic Dendritic Cells to Lymph Nodes, Impairing the Anticancer Immune Response.

Cancer immunology research·2024
Same author

Monocyte uptake of polymeric peptidoglycan is bimodal and governed by complement C3 and C4 opsonins.

JCI insight·2024
Same journal

IL-33 scripts cancer immunity.

Trends in immunology·2026
Same journal

Mitochondrial Ca<sup>2+</sup> signaling: A metabolic rheostat defining tumor and immune cell fate.

Trends in immunology·2026
Same journal

Cross-priming underlies the efficacy of antibody-drug conjugates and immunotherapy combinations.

Trends in immunology·2026
Same journal

Gut microbiome metabolites meet immunometabolism in inflammatory bowel disease.

Trends in immunology·2026
Same journal

Metabolic regulatory nodes of the inflammasome and inflammatory cell death.

Trends in immunology·2026
Same journal

Parental leave in immunology - 6.

Trends in immunology·2026
See all related articles

Complement proteins have novel roles beyond inflammation, influencing cell development and regeneration. These findings reveal innate immunity

Area of Science:

  • Immunology and Developmental Biology
  • Innate Immunity and Cellular Signaling

Background:

  • Complement proteins traditionally known for inflammatory roles.
  • Emerging evidence suggests broader functions in cellular processes.
  • These functions are critical for development and tissue repair.

Purpose of the Study:

  • To explore novel, non-inflammatory functions of complement proteins.
  • To understand complement's role in cell modulation during development and regeneration.
  • To investigate interactions between complement pathways and other signaling networks.

Main Methods:

  • Review of recent studies and accumulating evidence.
  • Analysis of complement's involvement in diverse biological processes.
  • Examination of complement-regulated pathways in developmental programs.

Related Experiment Videos

Main Results:

  • Complement proteins modulate cellular responses and cell-cell interactions.
  • Complement plays roles in hematopoiesis, skeletal, vascular development, and reproduction.
  • Complement pathways interact with signaling networks influencing regeneration (e.g., limb, organ).

Conclusions:

  • Complement possesses significant, under-appreciated roles in normal development.
  • Innate immunity's role in cell modulatory pathways is illuminated by complement research.
  • Findings have implications for understanding development and regenerative medicine.