Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Temporopolar changes in temporal lobe epilepsy: a quantitative MRI-based study.

S Coste1, P Ryvlin, M Hermier

  • 1Department of Functional Neurology and Epilepsy, Neurological Hospital, Lyon, France.

Neurology
|September 26, 2002
PubMed
Summary

Temporal lobe epilepsy (TLE) is associated with atrophy in the temporal pole (TP), particularly the white and gray matter. This TP atrophy often indicates the seizure origin and may share a common cause with white matter signal changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional mapping of the human insula: Data from electrical stimulations.

Revue neurologique·2019
Same author

Can you guess the colour of this moving object? A dissociation between colour and motion in blindsight.

Neuropsychologia·2018
Same author

[Electrophysiological testing in spinal cord tumors].

Neuro-Chirurgie·2017
Same author

Epileptic networks in patients with bitemporal epilepsy: the role of SEEG for the selection of good surgical candidates.

Epilepsy research·2016
Same author

Somatosensory evoked potentials in the assessment of peripheral neuropathies: Commented results of a survey among French-speaking practitioners and recommendations for practice.

Neurophysiologie clinique = Clinical neurophysiology·2015
Same author

H.M. never again! An analysis of H.M.'s epilepsy and treatment.

Revue neurologique·2015

Area of Science:

  • Neuroimaging
  • Epilepsy Pathophysiology
  • Brain Morphology

Background:

  • Temporal lobe epilepsy (TLE) is a common neurological disorder.
  • Anterior temporal white matter increased T2 signal is a known MRI finding in TLE.
  • The underlying pathophysiology of this white matter signal change and its relation to temporal pole structures is not fully understood.

Purpose of the Study:

  • To quantify morphologic changes in temporopolar structures in TLE patients.
  • To investigate the relationship between temporal pole (TP) volume and MRI findings, including anterior temporal white matter increased T2 signal.
  • To understand the pathophysiology of TLE.

Main Methods:

  • MRI scans of 30 TLE patients and 30 controls were analyzed.
  • Three-dimensional T1 MR images were used for semiautomatic measurement of TP gray and white matter volumes.

Related Experiment Videos

  • Statistical analyses assessed associations between TP volume, T2 signal, hippocampal sclerosis, and clinical variables.

    • Main Results:

    • Patients with TLE showed reduced ipsilateral TP white and gray matter volumes.
    • Abnormal TP volume correctly lateralized the epileptogenic zone in 72% of patients.
    • Increased T2-weighted signal in anterior temporal white matter correlated with greater TP volume asymmetry.

    Conclusions:

    • The temporal pole is frequently atrophic in patients with refractory TLE, ipsilateral to seizure onset.
    • TP atrophy and increased white matter T2 signal may stem from a shared pathological process.
    • TP volume measurement is a valuable tool for lateralizing the epileptogenic zone in TLE.