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Systemic candidiasis in intensive care units: a multicenter, matched-cohort study
Ghislaine Leleu1, Philippe Aegerter, Bertrand Guidet
1Medical Intensive Care Unit, Hôpital Saint Louis, Vellefaux, Paris, France.
Journal of Critical Care
|September 26, 2002
Summary
Systemic Candida infections significantly increase mortality and hospital stay for intensive care unit (ICU) patients. Prompt management of these serious infections is crucial for better patient outcomes.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Mycology
Background:
- Systemic candidiasis poses a significant threat to critically ill patients.
- Understanding its impact on mortality and resource utilization is vital for healthcare management.
Purpose of the Study:
- To evaluate the effect of systemic candidiasis on mortality and hospital stay duration in intensive care unit (ICU) patients.
- To assess the associated healthcare workload.
Main Methods:
- A multicenter, retrospective, matched-cohort study was conducted.
- Data from 32 ICUs in Paris, France, were analyzed.
- 149 patients with systemic candidiasis were matched with 121 controls.
Main Results:
- Patients with systemic candidiasis experienced significantly longer ICU stays (25 vs. 10 days).
- Systemic candidiasis was associated with a 2.27-fold increased risk of death (P =.001).
- No significant difference in outcomes was observed between patients with and without positive blood cultures.
Conclusions:
- Systemic Candida infections markedly increase mortality and morbidity in severely ill ICU patients.
- Optimizing the management of systemic candidiasis is essential.