[Is alternative splicing of mammalian genes conservative?]
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Updated: Sep 29, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
R N Nurtdinov1, A A Mironov, M S Gel'fand
1Physical Department, Lomonosov Moscow State University, Vorob'evy Gory, 119899 Russia.
Abstract:
The conservation of alternative splicing in orthologous genes from the human and mouse genomes was analyzed. Alternatively spliced mouse genes from the AsMamDB database were used to scan the draft human genome. The mouse protein isoforms were aligned with respect to orthologous human genes, and thus the exon-intron structure of the latter was established. Proteins isoforms that could not be aligned throughout their length were analyzed in detail using the human EST alignment.
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