[Histochemical aspects in carrageenan induced inflammation]

Some changes of groundsubstance and cell proliferation are histochemically demonstrated in the carrageenin induced edema, in the connective tissue of the rat hund paw. We observed, that the leucocytic infiltration (beginning 5 minutes after inflammation) and the desintegration of these cells, induced by liberated lysosomal enzymes, can be assumed to be connected with mastcell degeneration. Fibroblasts and mastcells are correlating in the phase of woundhealing. Iron, which is found in the phagocytes of the connective tissue, in the acute stage of inflammation may not only be a consequence of the desintegration of erythrocytes, its appearance could be interpreted as support of the hypothesis of its antitoxic function.