Neuroendocrine regulation of LHRH and gonadotropin

Analysis of gonadotropin secretion patterns throughout the menstrual cycle revealed a complex rhythm. Especially at 1-3 hour intervals this was seen, with a frequency that was dependent on the phase of the menstrual cycle. There is little information available concerning the role of plasma luteinizing hormone-releasing hormone (LHRH) in the regulation of donadotropin secretion in amenorrheic and postmenopausal women. In this paper, the authors present the results of a detailed investigation into the secretory pattern of LH, follicle stimulating hormone, and LHRH in normal women with a normal menstrual cycle, amenorrheic women, and postmenopausal women.