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Intracranial hemorrhage in neuro-Behçet's syndrome
Seiji Kikuchi1, Masaaki Niino, Kazuyoshi Shinpo
1Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo.
Objective:
Most cerebrovascular disturbances in Behçet's syndrome are occlusive in nature, while hemorrhage is rare. In this paper, we report three cases of neuro-Behçet's syndrome presenting with intracerebral hemorrhaging, and discuss the possible causes as they relate to cyclosporine treatment.
Patients:
Three cases of neuro-Behçet's syndrome presented with intracranial hemorrhage. One patient had been taking cyclosporine, and the other two patients had never taking cyclosporine.
Results:
Together with previous reports, these cases suggest that there are two types of intracranial hemorrhage in neuro-Behçet's syndrome. One type occurs in the center of a lesion and during the acute phase of the disease, while the other occurs in the peripheral lesion and during the subacute phase.
Conclusions:
It appears that the intracranial hemorrhages in neuro-Behçet's syndrome can be divided into two groups. It is possible that the vascular pathologies caused by Behçet's syndrome and by cyclosporine conspire to induce CNS hemorrhaging in some cases.