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A general method for the enantioselective synthesis of pantolactone derivatives
David A Evans1, Jimmy Wu, Craig E Masse
1Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA. evans@chemistry.harvard.edu
Organic Letters
|September 27, 2002
Abstract:
An efficient enantioselective synthesis of beta,beta-dialkyl-gamma-substituted pantolactones has been achieved utilizing the cationic [Sc((S,S)-R-pybox)](Cl)(2)(+), R = Ph (9), t-Bu (10), complex in a catalyzed aldol reaction as the key step. The pantolactone derivatives are isolated in high enantiomeric excesses. [reaction: see text]