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Updated: Aug 5, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Modified gamma-cyclodextrins and their rocuronium complexes
K S Cameron1, J K Clark, A Cooper
1Departments of Analytical and Medicinal Chemistry, Organon Laboratories Ltd., Newhouse ML1 5SH, Scotland, U.K.
Abstract:
A series of per-6-substituted cyclodextrin derivatives was synthesized as synthetic host molecules for rocuronium, a steroidal muscle relaxant. By forming host-guest complexes with rocuronium, these cyclodextrin derivatives reverse the muscle relaxation induced by rocuronium in vitro and in vivo. The isothermal microcalorimetry data are consistent with the biological data supporting the encapsulation mechanism of action. Binary and biphasic complexes are reported with NMR experiments clearly showing free and bound rocuronium. [structure: see text]
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