Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estrogen therapy for hepatectomy patients with poor liver function?

E-J Chiu1, H-L Lin, C-W Chi

  • 1Department of Surgery, Veteran General Hospital-Taipei, Taipei, Taiwan, Republic of China.

Medical Hypotheses
|September 27, 2002
PubMed
Summary

Estradiol and Interleukin-6 (IL-6) may synergize to enhance liver regeneration after surgery. Short-term estradiol treatment could benefit patients with impaired liver function post-hepatectomy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of polygenic risk score for triglyceride trajectory and diabetic complications in subjects with type 2 diabetes based on large electronic medical record data from Taiwan: a case control study.

Journal of endocrinological investigation·2024
Same author

Incidence and familial clustering of infantile haemangiomas: a multicentre study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Healing of sub-critical femoral osteotomies in mice is unaffected by tacrolimus and deletion of recombination activating gene 1.

European cells & materials·2021
Same author

The inverted T wave: type B Wellens' syndrome.

QJM : monthly journal of the Association of Physicians·2021
Same author

Blockade of fatty acid signalling inhibits lipopolysaccharide-induced macrophage recruitment and progression of apical periodontitis.

International endodontic journal·2020
Same author

Prognostic Impact of Delirium in Older People With/Without Dementia: A Retrospective Cohort Study in Taiwan.

The journal of nutrition, health & aging·2020

Area of Science:

  • Hepatology
  • Endocrinology
  • Molecular Biology

Background:

  • Estrogen, particularly estradiol, is recognized for promoting liver regeneration following partial hepatectomy.
  • Endogenous aromatase, crucial for testosterone to estradiol conversion, is induced by Interleukin-6 (IL-6), a key liver regeneration factor.

Purpose of the Study:

  • To investigate the synergistic role of estradiol and IL-6 in stimulating hepatocyte proliferation during liver regeneration.
  • To explore the potential therapeutic benefit of short-term estradiol administration in patients with compromised liver function after hepatectomy.

Main Methods:

  • The study examines the interplay between IL-6 signaling pathways (STAT1/3) and aromatase activity in hepatocytes.
  • Serum estradiol levels were correlated with IL-6 induction and hepatocyte DNA synthesis post-hepatectomy.

Related Experiment Videos

Main Results:

  • IL-6 induces aromatase activity, leading to elevated serum estradiol levels after partial hepatectomy.
  • Estradiol and IL-6 signaling pathways appear to work together to promote hepatocyte proliferation.

Conclusions:

  • Estradiol and IL-6 likely synergize to stimulate hepatocyte proliferation, enhancing liver regeneration.
  • Short-term estradiol treatment may offer a beneficial strategy for improving liver function in post-hepatectomy patients with poor liver function.