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Toward bioengineering anticancer drugs
1Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA.
Chemistry & Biology
|September 27, 2002
Abstract:
The biosynthetic route for enediyne production remained mysterious until two independent groups recently reported the genes that orchestrate enediyne synthesis in two different microorganisms. These discoveries lay the foundations for engineering this pathway to generate improved anticancer drugs.