In vivo voltammetry and concomitant electrophysiology at a single micro-biosensor to analyse ischaemia, depression...

Electrochemical methods such as voltammetry can be used to understand patho-physiological mechanisms of action and, therefore, develop therapeutic approaches. In particular, voltammetry with treated micro-biosensors (carbon fibre micro-electrodes, mCFE) has been used to study models of (1) ischaemia; (2) drug dependence, and in particular craving; (3) depression. In addition, in studies (1) and (3) concomitant in vivo voltammetric and electrophysiological analysis has been performed by means of the same mCFE. Original data concerning ascorbate release in ischaemia, peptidergic activity during craving for drugs of abuse and concomitant voltammetric and electrophysiological changes of the serotonergic system in rats submitted to forced swimming test or to pharmacological treatment with the selective serotonin reuptake inhibitor fluoxetine are shown and discussed.