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Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia
Jaana Laasanen1, Seppo Heinonen, Mikko Hiltunen
1Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland.
Objective:
To investigate peroxisome proliferator-activated receptor-gamma (PPARgamma) genotype frequencies in women with preeclampsia and elucidate its role in the pathogenesis of preeclampsia.
Methods:
The study involved 133 preeclamptic and 115 healthy control women who were genotyped for a known functional variant of the PPARgamma gene using single-strand conformation polymorphism (SSCP) analysis.
Results:
We found no association between PPARgamma polymorphism and the occurrence of preeclampsia. In affected women, the clinical course of preeclampsia was no different among the three PPARgamma genotypes.
Conclusion:
Our data does not support a role for PPARgamma gene polymorphism in the pathogenesis of preeclampsia. Accordingly, it is unlikely that PPARgamma polymorphism influences the severity of preeclampsia.
Precis:
There is no association between PPARgamma polymorphism and the occurrence or severity of preeclampsia.
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