Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antioxidant capacity after acute ischaemic stroke.

S E Gariballa1, T P Hutchin, A J Sinclair

  • 1Sheffield Institute For Studies on Ageing, University of Sheffield, Northern General Hospital, Sheffield, UK. s.e.gariballa@sheffield.ac.uk

QJM : Monthly Journal of the Association of Physicians
|September 27, 2002
PubMed
Summary

Acute ischemic stroke patients show reduced total antioxidant capacity (TAC) and vitamin C levels, despite increased uric acid. Oxidative damage markers were elevated, indicating impaired antioxidant defenses post-stroke.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Criteria of frail older people with type 2 diabetes who are suitable for SGLT-2 inhibitors and GLP-1RA therapy.

Journal of diabetes and its complications·2025
Same author

Type 1 Diabetes in care homes: A practical guide on management.

Diabetic medicine : a journal of the British Diabetic Association·2024
Same author

Enhancing diabetes care for the most vulnerable in the 21st century: Interim findings of the National Advisory Panel on Care Home Diabetes (NAPCHD).

Diabetic medicine : a journal of the British Diabetic Association·2023
Same author

Editorial: COVID-19 Infection in Frailty - Still Plenty of Research Needed but Making Progress.

The journal of nutrition, health & aging·2023
Same author

Discovery and insights from DSX mission's high-power VLF wave transmission experiments in the radiation belts.

Scientific reports·2022
Same author

Metabolic phenotypes explain the relationship between dysglycaemia and frailty in older people with type 2 diabetes.

Journal of diabetes and its complications·2022

Area of Science:

  • Biochemistry
  • Neurology
  • Clinical Medicine

Background:

  • Acute stroke triggers rapid oxidative damage due to reperfusion following ischemia.
  • Endogenous antioxidant defenses are depleted, exacerbating tissue damage post-stroke.

Purpose of the Study:

  • To quantify changes in individual and total antioxidant capacity in stroke patients within a defined timeframe post-infarct.
  • To investigate the relationship between antioxidant markers and oxidative stress in acute ischemic stroke.

Main Methods:

  • Observational cohort study involving 31 acute ischemic stroke patients, 26 non-stroke hospitalized patients, and 23 healthy controls.
  • Blood samples were collected at multiple time points post-stroke onset (within 24h, 48-72h, 7 days).
  • Assayed markers included Vitamins E and C, glutathione, total antioxidant capacity (TAC), uric acid, thiobarbituric-acid-reactive substances (TBARS), albumin, transferrin, and C-reactive protein (CRP).

Related Experiment Videos

Main Results:

  • Ischemic stroke patients exhibited significantly higher TBARS (oxidative damage marker) and lower baseline glutathione compared to controls.
  • Serum total antioxidant capacity (TAC) was reduced in stroke patients, despite elevated uric acid levels, which strongly correlated with TAC.
  • Serum vitamin C concentrations significantly deteriorated in stroke patients compared to controls.

Conclusions:

  • Stroke patients demonstrate reduced total antioxidant capacity and vitamin C levels, suggesting compromised antioxidant defenses.
  • Elevated uric acid in stroke patients did not fully compensate for the reduction in overall antioxidant capacity.
  • These findings highlight the significant impact of acute ischemic stroke on the body's antioxidant status.